{"id":3535,"date":"2025-07-31T12:35:51","date_gmt":"2025-07-31T10:35:51","guid":{"rendered":"https:\/\/beta.pharmadiet.com\/?post_type=product&#038;p=3535"},"modified":"2025-11-15T21:39:39","modified_gmt":"2025-11-15T20:39:39","slug":"cognidine","status":"publish","type":"product","link":"https:\/\/beta.pharmadiet.com\/uk\/productos\/cognidine\/","title":{"rendered":"Cognidine\u00ae"},"content":{"rendered":"<ul>\n<li>Chicken protein-free<\/li>\n<li>Without preservatives.<\/li>\n<li>No artificial colorings<\/li>\n<li>Suitable modes of use according to the weight of the pet<\/li>\n<li>Easily divisible tablets.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Complementary feed whose combination of nutrients helps maintain normal cognitive function in dogs and cats.<\/p>\n","protected":false},"featured_media":3536,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"animal":[117,119],"product_brand":[],"product_cat":[23],"product_tag":[278],"class_list":{"0":"post-3535","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"animal-cat","7":"animal-dog","8":"product_cat-behavior-supplements-animals","9":"product_tag-plantillab","10":"desktop-align-left","11":"tablet-align-left","12":"mobile-align-left","14":"first","15":"instock","16":"shipping-taxable","17":"product-type-simple"},"acf":{"title_indications":"","description_indication":"","items_indication":[{"imagen":3538,"title":"Cognitive Dysfunction in Dogs and Cats","description":"Cognitive Dysfunction Syndrome (CDS) in cats and dogs is a clinical condition that affects older pets, characterised by a series of neurological disorders that negatively impact their cognitive functions, changes in behavior, social interactions, and quality of life.\r\n\r\nClinical signs include:\r\n<ul>\r\n \t<li>Changes in interaction with owners or other animals.<\/li>\r\n \t<li>Disorientation and confusion, anxiety, and restlessness.<\/li>\r\n \t<li>Sleep-wake cycle disorders, changes in behavior patterns.<\/li>\r\n \t<li>Alterations in daily routines.<\/li>\r\n \t<li>Changes in motor function.<\/li>\r\n<\/ul>\r\nCDS has become an increasingly important area of research and veterinary care. Early diagnosis and appropriate intervention are key to addressing this syndrome."},{"imagen":3539,"title":"Factors Associated with Cognitive Dysfunction Syndrome in Dogs and Cats","description":"CDS manifests in various ways:\r\n<ul>\r\n \t<li>Macroscopic changes in the brain: cortical atrophy, which affects areas of the brain related to memory and learning, as well as the hippocampus, a structure that contributes to the formation of new memories.<\/li>\r\n \t<li>Neuronal changes: such as the loss of nerve cells in key brain areas.<\/li>\r\n \t<li>Oxidative damage and inflammation: leading to the deterioration of proteins, lipids, and nucleotides in the brain, eventually resulting in neuron death.<\/li>\r\n \t<li>Accumulation of \u00df-amyloid protein: may contribute to neuronal loss and brain atrophy.<\/li>\r\n<\/ul>\r\nCDS can also result from cerebrovascular pathologies: cerebral vascular changes, gliosis, and ventricular dilation, leading to cerebral atrophy, ventricular enlargement, and lesions in the medial temporal lobes."}],"title_beneficios":"How the nutrients in the complementary feed Cognidine\u00ae help pets","description_benefits":"Cognidine\u00ae provides nutrients to help:\r\n\r\n&nbsp;","items_benefits":[{"imagen":1238,"title":"Maintain the cognitive system of senior dogs and cats.","description":""}],"items_presentaciones":[{"title":"Cognidine\u00ae","description":"Box with 60 tablets, in blister packs of 10 tablets each.\r\n\r\n&nbsp;","imagen":3536}],"description_ingredients":"","items_ingredients":[{"title":"Uridine<sup>1,2<\/sup>","description":"Essential nucleotide in the biosynthesis of phospholipids and glycolipids in cell membranes, such as neurons.\r\n\r\n&nbsp;"},{"title":"Dried apple pulp","description":"Provides polyphenols and quinones.\r\n\r\n&nbsp;"},{"title":"Tryptophan<sup>5,6<\/sup>","description":"Precursor of the neurotransmitter Serotonin, essential for mood regulation, behavior, and anxiety.\r\n\r\n&nbsp;"},{"title":"Biotin\r\n\r\n&nbsp;","description":"Contributes to the normal functioning of the nervous system and normal psychological function.\r\n\r\n&nbsp;"},{"title":"Selenium and Zinc\r\n\r\n&nbsp;","description":"Contribute to cellular protection against oxidative damage.\r\n\r\n&nbsp;"},{"title":"Barley bran\r\n\r\n&nbsp;","description":"Provides Astaxanthin and Omega 3.\r\n\r\n&nbsp;"}],"video":"","items_Instructions_for_use":[{"title":"Cat","description":"1 tablet per day.\r\n\r\n&nbsp;"},{"title":"Dog","description":"<ul>\r\n \t<li><strong>Up to 10 kg:<\/strong> 1 tablet per day.<\/li>\r\n \t<li><strong>10 to 20 kg:<\/strong> 2 tablets per day.<\/li>\r\n \t<li><strong>20 to 30 kg:<\/strong> 3 tablets per day.<\/li>\r\n \t<li><strong>30 to 40 kg:<\/strong> 4 tablets per day.<\/li>\r\n \t<li><strong>Over 40 kg:<\/strong> 5 tablets per day.<\/li>\r\n<\/ul>"},{"title":"Other indications","description":"Oral route\r\n\r\nIf preferred, mix with the usual food.\r\n\r\nAs it is a dietary supplement, it can be administered continuously."}],"image_banner_scientific_study_copiar":"","title_banner_scientific_study":"","description_banner_scientific_study":"","Scientific_study_banner":"","studies":null,"bibliografy_text":"<ol>\r\n \t<li>Wattig B et al. Acceleration of nerve and muscle regeneration by administration of nucleotides\u2013electroneurophysiological and morphometrical investigations. Acta Histochem Suppl. 1992;42:333-9.<\/li>\r\n \t<li>Chen TH et al. A nucleoside-nucleotide mixture may reduce memory deterioration in old senescence-accelerated mice. . J Nutr. 2000 Dec;130(12):3085-9.<\/li>\r\n \t<li>Harris CB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.1. J Nutr Biochem. 2013 Dec;24(12):2076-84.<\/li>\r\n \t<li>He B. Effects of pyrroloquinoline quinine on oxidative stress- induced apoptosis of Schwann cells and its mechanism. Zhonghua Zheng Xing Wai Ke Za Zhi. 2014 Mar;30(2):111-7<\/li>\r\n \t<li>Silber BY. Effects of tryptophan loading on human cognition, mood, and sleep. Neuroscience and Biobehavioral Reviews .2010; 34: 387\u2013407.<\/li>\r\n \t<li>Jean S. DeNapoli. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. 2000; JAVMA, Vol 217, No. 4.<\/li>\r\n \t<li>Murphy T, et al. Effects of diet on brain plasticity in animal and human Studies: mind the gap. Neural Plasticity.2014; ID 563160.<\/li>\r\n<\/ol>","features":[{"image":1262,"title":"Chicken protein-free"},{"image":1267,"title":"Without preservatives."},{"image":1213,"title":"Easily divisible tablets."}],"ficha_tecnica":3553},"_links":{"self":[{"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product\/3535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/comments?post=3535"}],"version-history":[{"count":12,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product\/3535\/revisions"}],"predecessor-version":[{"id":17380,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product\/3535\/revisions\/17380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/media\/3536"}],"wp:attachment":[{"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/media?parent=3535"}],"wp:term":[{"taxonomy":"animal","embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/animal?post=3535"},{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product_brand?post=3535"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product_cat?post=3535"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/beta.pharmadiet.com\/uk\/wp-json\/wp\/v2\/product_tag?post=3535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}